In this continuing saga of the bizarre life of a faithless Texas preacher, Jesse Custer heads to the south to confront the extremely dysfunctional family that abused him as a child and planted the original seeds of his disillusionment with the world. Now merged with a half angelic, half demonic being, the former preacher looks to exact revenge against those who simultaneously raised and destroyed him. Then after exorcising his personal demons, Jesse, his girlfriend Tulip, and their friend Cassidy, the Irish vampire, head west to a party of Babylonian proportions.